Click on a link below to view more about each clinical trial

Paroxysmal Nocturnal Hemoglobinuria #1058
The PNH Patient Registry is a prospective, long-term, multi-center, multi-national, observational research initiative, compiling data on the natural history and management of patients diagnosed with PHN.

Breast Cancer #1122
TAILORx is the first trial that has been developed as a result of the NCI’s “Program for the Assessment of Clinical Cancer Tests,” (PACCT). The study population will include patients with estrogen-receptor (ER) positive, axillary lymph node negative breast cancer.

Hip Replacement #1174
The purpose of this study is to determine the mid and long-term safety and effectiveness of a new hip replacement device.

Multiple Myeloma #1250
The purpose of this study is to collect information on disease and medical treatment that doctors are already collecting as part of normal care.

Chronic Lymphocytic Leukemia $1273
This is an observation study, which means it is a study that does not prescribe research medication or require additional medical treatment.  The purpose of this study is to collect information on disease and medical treatment that is already collected as part of normal care.

Multiple Sclerosis #1341
Long-term, prospective, observational, multinational, parallel-cohort study monitoring safety in patients with MS newly started with fingolimod once daily or treated with another approved disease-modifying therapy.

Breast Cancer #1391
This research is being done to find out more about the treatment of cancer that has either grown beyond the usual limits of the breast or has spread to areas of the body that are distant to it.

Hip Replacement #1413
The purpose of this study is to collect and evaluate outcomes data on patients who have undergone hip surgery with devices manufactured and/or distributed by Exactech, Inc.

Knee Replacement #1414
The purpose of this study is to collect and evaluate outcomes data on subjects who have undergone, or will undergo, knee joint replacement surgery.

COPD #1422
The overall objective of this study is to develop and validate a health insurance claims-based algorithm to identify COPD exacerbation events (AECOPD) based on ICD-9-CM diagnosis codes, Current Procedural Terminology (CPT) codes, Healthcare Common Procedure Coding System (HCPCS) procedure codes, Nation Drug Codes (NDC), Medicare Severity- Diagnosis-Related Group (MS_DRG) codes and acute outpatient care data.

Cardiovascular Inflammation Reduction Trial (CIRT) #1483
Investigators will evaluate whether low-dose methotrexate will reduce rates of myocardial infarction, stroke, or cardiovascular death among patients with a recent history of coronary artery disease and either type II diabetes or metabolic syndrome.

Non-Small Cell Lung Cancer #1501
The purpose of the study is to compare BI 695502 (the study drug) to Avastin.  Avastin has been shown to be effective in patients with a type of lung cancer called non-squamous non-small cell lung cancer (nsNSCLC) in association with chemotherapy.

Fall Prevention #1503
The aim of this pragmatic cluster-randomized trial is to determine the effectiveness of an evidence-based, patient-centered multifactorial fall injury prevention strategy in community dwelling older adults at risk of falls recruited from 86 primary care practices around the U.S.

Retinal Detachment #1504
Collaborating with University of Massachusetts Lowell to conduct a study on vision and eye health to help us better understands general eye health, as well as myopia (near sightedness), retinal detachments and retinal tears.  This is a survey study.

Pancreatic Cancer #1508
For patients with metastatic pancreatic cancer who have already progressed or failed therapy on a gemcitabine-based first line regimen.

Non-Small Cell Lung Cancer #1515
For elderly patients (≥ 70 years old) with advanced non-small cell lung cancer.

Febrile Neutropenia #1517
Development of Risk-Prediction Models for Chemotherapy-Induced Febrile Neutropenia in Patient with Breast Cancer, Colorectal Cancer, Lung Cancer and Non-Hodgkin’s Lymphoma.

Polycythemia Vera #1518
This is a Phase IV, multicenter, non-interventional, non-randomized, prospective, observational study in an adult population of men and women who have been diagnosed with clinically overt PV and are being followed in either community or academic medical centers in the United States who will be enrolled over a 12 -month period and observed for 36 months from the date the last patient is enrolled.

Genetic Study for Healthy Non-Smokers #1441
Phase II of the COPD Gene study aims to improve the diagnosis and treatment of lung disease for millions of people affected by chronic obstructive pulmonary disease (COPD), and is being conducted by several groups of doctors and scientists throughout the U.S.

Osteoarthritis requiring Hip Replacement #1174
The purpose of this study is to determine the mid and long-term safety and effectiveness of a new hip replacement device. This is a post marketed study looking at a specific type of hip replacement device using ceramic.

Prostate Cancer #2562
The purpose of this registry is to describe patterns of care, disease assessment methods, treatment decisions, treatment settings, physician referral patterns and to find out how a patient’s CRPC symptoms have improved while on CRPC therapy.

Medication Safety #2564
This study is a randomized controlled trial focused on older patients recently discharged from the hospital who have been prescribed medications within one of three high-priority, high-risk drug classes.

Chronic Lymphocytic Leukemia #2565
The purpose of the study is to determine how effective the combination of an investigational new drug (ublituximab) and another currently FDA approved drug ibrutinib (also referred to as Imbruvica) is when given to human patients.

Pancreatic #2568

The purpose of this research study is to find out more about the investigational drug, MM-141 and how it interacts with nab-paclitaxel and gemcitabine in patients with newly diagnosed metastatic pancreatic cancer.

Dementia #2571
The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) Study will establish an open-label, longitudinal cohort study to assess the impact of amyloid PET on patient outcomes.

Technology #2570
We believe that real-time messaging will make some ER transports, expensive tests, and hospital admissions unnecessary; as well as help ensure follow-ups and/or increased home services in order to reduce subsequent ER visits and readmissions.

Breast Cancer #2577
The purpose of the study is to investigate an experimental drug called SPI-2012. The purpose of this study is to compare SPI-2012 and pegfilgrastim, while receive chemotherapy with docetaxel and cyclophosphamide (also called TC chemotherapy) for early stage breast cancer.

Small Cell Lung Cancer #2583
A randomized, open label phase 3 study of irinotecan liposome injection (ONIVYDE®) versus topotecan in patients with small cell lung cancer who have progressed on or after platinum-based first-line therapy